Francois Coty was among the first perfumers to use synthetics along with natural essences, the deciding factor in making perfume an affordable luxury for the masses. Due to their low price and stability, synthetics were heavily promoted and soon replaced natural essences in the manufacturing of perfume, except for the florals, florals were extremely difficult to replicate.
Synthetics provided a realiability that natural essences did not. The time that it took to procure, seperate, purify, recombinate and effect the necessary outcome was no longer feasible as societies grew and more individuals wanted to experience the olfactory journey that perfume created.
Today there are several thousand synthetically produced aroma chemicals potentially available to the perfumer.